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Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

《医学前沿（英文）》 2009年 第3卷 第2期   页码 164-170 doi: 10.1007/s11684-009-0038-1

摘要： The invasion and metastasis of breast cancer are supposed to involve several stages in which epithelial-mesenchymal transition (EMT) is regarded as the mechanistic basis for the behavior of cancer cells. A series of factors related to EMT are apparently involved in such process. The current study aimed to investigate the contributions of EMT and related factors in lymph node metastasis of breast cancer. The expressions of E-cadherin (E-Cad), N-cadherin (N-Cad), vascular endothelial cell growth factor (VEGF), matrix metalloproteinase-9 (MMP-9), cyclooxygenase-2 (COX-2), and CD34 were examined in 74 cases of breast cancer, including 39 cases with lymph node metastasis and 35 cases without lymph node metastasis by immunohistochemistry. Multivariable Cox proportional hazards model was used to analyze the patients’ prognosis. The expressions of N-Cad, VEGF, MMP-9, and COX-2 in cases with lymph node metastasis were significantly higher than those without lymph node metastasis ( <0.05), while the E-Cad level was inversely related to status of lymph node metastasis ( <0.05). The metastasis rate of lymph node in the cases with EMT (lower E-Cad expression and higher N-Cad expression) was 78.3%, while that without EMT (higher E-Cad expression and lower N-Cad expression) was 11.1%. There was a statistical difference in the expression of COX-2 protein between histological grade I and grade II or III, respectively ( <0.05). In the cases with higher grade, the expression of E-Cad was decreased, while that of N-Cad was increased. Higher microvascular density (MVD) was also found to be significantly associated with lymphatic metastasis ( <0.05), and the cases with higher MVD had shorter survival time. This study indicates that EMT and expressions of VEGF, MMP-9 and COX-2, and MVD value are strongly correlated with lymph node metastasis in breast cancer.

关键词： epithelial-mesenchymal transition     vascular endothelial cell growth factor     matrix metalloproteinase-9     cyclooxygenase-2     higher microvascular density     breast cancer    

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FUNCTIONAL GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OF

《农业科学与工程前沿（英文）》 2021年 第8卷 第2期

摘要：

Fruit cracking is a major disorder that affects the integrity of fruit and reduces the commercial value of tomato and other fleshy fruit. Here, we have found a novel fruit ‘netted-cracking’ (FNC) phenotype in tomato introgression line IL4-4 which is present in neither the donor parent (LA0716) nor the receptor parent (M82). An F2 population was generated by crossing IL4-4 with M82 to genetically characterize the FNC gene and this showed that a single dominant gene determined fruit netted-cracking. Further map-based cloning narrowed down the FNC locus to a 230 kb region on chromosome 4. Sequencing and annotation analysis show that FNC(Solyc04 g082540) was the most likely candidate gene. Functional characterization of FNC by overexpressing FNCAC and FNCIL4-4resulted in the fruit netted-cracking phenotype, suggesting that the FNC transcript level results in the functional gain of fruit netted-cracking. These findings were further confirmed by FNC ortholog in netted-cracking pepper and melon, indicating a common regulatory mechanism in different plant species. Furthermore, cytoplasm and nucleus-localized FNC indicates increased expression of genes involved in suberin, lignin, lipid transport and cell wall metabolism. These findings provide novel genetic insights into fruit netted-cracking and offer a way to promote molecular improvement toward cracking resistant cultivars.

 

关键词： fine mapping / fruit netted-cracking / introgression line / transcript level    

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Higher-order mode effects on the seismic performance of tall piers

Zhongguo GUAN, Jianzhong LI, Yan XU, Hao LU

《结构与土木工程前沿（英文）》 2011年 第5卷 第4期   页码 496-502 doi: 10.1007/s11709-011-0131-9

摘要： A comprehensive analysis was conducted to investigate the seismic performance of a typical tall bridge pier through incremental dynamical analysis (IDA). The effect of higher-order modes was studied specifically. The results showed that higher-order modes significantly contributed to the structural seismic response and should not be neglected. Including these modes resulted in an additional hinge midway up the pier. No plastic hinge would occur at this location for conventional bridge piers. Higher-order modes also led to an out-of-phase response between the hinge rotation at the pier bottom and the displacement at the top. This means that the displacement-based seismic design method cannot correctly predict the mechanical state of the critical hinge and therefore is not suitable for use in the seismic design of tall piers. Mistakenly using the displacement-based seismic design method for tall piers may result in a seriously unsafe condition.

关键词： tall bridges     higher-order mode effects     incremental dynamic analysis    

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高等植物叶片色域的理论研究

程晓舫,董金一,范学良,丁金磊

《中国工程科学》 2006年 第8卷 第12期   页码 66-69

摘要：

利用叶绿素和类胡萝卜素的经典吸收光谱以及植物叶片中不含色素的其他物质成分的光谱，分别求得其在CIE1931色品图中的理论坐标，并根据色度学中的加法混色原理确定出高等植物叶色的理论域范围。实验数据与理论相吻合。

关键词： 高等植物     色素     吸收光谱     色度坐标     色域    

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工程结构可靠性分析的高阶矩法研究

宫凤强,李夕兵,邓建

《中国工程科学》 2006年 第8卷 第5期   页码 69-73

摘要：

提出了工程结构可靠性分析的高阶矩方法。主要是基于数值逼近原理，以切比雪夫正交函数族{Tk(x)}做基，利用功能函数的高阶矩信息，通过计算功能函数概率密度函数的逼近表达式，然后根据工程结构可靠性的一般表达式来计算结构的失效概率，进行可靠性分析。通过经典分布函数的数值检验和结构构件失效概率的计算结果比较，表明了该方法在理论上的正确性和工程中的实用性。

关键词： 结构可靠性     高阶矩     切比雪夫多项式     失效概率    

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Higher heating value prediction of torrefaction char produced from non-woody biomass

Nitipong SOPONPONGPIPAT,Dussadeeporn SITTIKUL,Unchana SAE-UENG

《能源前沿（英文）》 2015年 第9卷 第4期   页码 461-471 doi: 10.1007/s11708-015-0377-3

摘要： The higher heating value of five types of non-woody biomass and their torrefaction char was predicted and compared with the experimental data obtained in this paper. The correlation proposed in this paper and the ones suggested by previous researches were used for prediction. For prediction using proximate analysis data, the mass fraction of fixed carbon and volatile matter had a strong effect on the higher heating value prediction of torrefaction char of non-woody biomass. The high ash fraction found in torrefied char resulted in a decrease in prediction accuracy. However, the prediction could be improved by taking into account the effect of ash fraction. The correlation developed in this paper gave a better prediction than the ones suggested by previous researches, and had an absolute average error (AAE) of 2.74% and an absolute bias error (ABE) of 0.52%. For prediction using elemental analysis data, the mass fraction of carbon, hydrogen, and oxygen had a strong effect on the higher heating value, while no relationship between the higher heating value and mass fractions of nitrogen and sulfur was discovered. The best correlation gave an AAE of 2.28% and an ABE of 1.36%.

关键词： higher heating value     correlation     biomass     proximate analysis     ultimate analysis    

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Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)

《医学前沿（英文）》 2022年 第16卷 第1期   页码 126-138 doi: 10.1007/s11684-021-0897-7

摘要： This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai, China. A total of 173 235 patients with type 2 diabetes in 2017 were included in the analysis. Profiles of risk factors and intermediate outcomes were determined. The patients had a mean age of 66.43±8.12 (standard deviation (SD)) years and a mean diabetes duration of 7.95±5.53 (SD) years. The percentage of patients who achieved the target level for HbA1c (<7.0%) was 48.6%. Patients who achieved the target levels for blood pressure (BP)<130/80 mmHg and low-density lipoprotein-cholesterol (LDL-c)<2.6 mmol/L reached 17.5% and 34.0%, respectively. A total of 3.8% achieved all three target levels, and the value increased to 6.8% with an adaptation of the BP target level (<140/90 mmHg) for those over 65 years. Multivariable analysis identified the factors associated with a great likelihood of achieving all three target levels: male, young age, short diabetes duration, low body mass index, macrovascular complications, no microvascular complications, prescribed with lipid-lowering medication, and no prescription of antihypertensive medication. In conclusion, nearly 50% and one-third of the patients with diabetes met the target levels for HbA1c and LDL-c, respectively, with a low percentage achieving the BP target level. The percentage of patients who achieved all three target levels needs significant improvement.

关键词： type 2 diabetes     quality of care     macrovascular complication     microvascular complication     treatment pattern     epidemiology    

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Effect of current density on groundwater arsenite removal performance using air cathode electrocoagulation

《环境科学与工程前沿（英文）》 2021年 第15卷 第6期 doi: 10.1007/s11783-021-1399-1

摘要：

• With the same charge, current density had little effect on As(III) removal in ACEC.

关键词： Electrocoagulation     Air cathode     Arsenic     Current density     Energy consumption    

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Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

《医学前沿（英文）》 2009年 第3卷 第3期   页码 323-329 doi: 10.1007/s11684-009-0061-2

摘要： The purpose of this article is to determine the effect of a well-designed combined aerobic, resistance, and extension exercise program on bone mineral density (BMD) in postmenopausal women. The population comprised 45 postmenopausal women, who exercised over 12months (exercise group), and 36 women who served as a non-training control group. BMD of the hip, and lumbar spine was measured at the baseline and 12th month. Repeated measurement analysis of variance and nonparametric test were utilized to compare differences between the exercise group and controls. Thirty-six out of 45 persons in the exercise group and 36 controls completed the study. Average compliance was 82.2% for the whole exercise group at the 12th month. All the subjects had decreased BMD, but the rate of bone loss was lower in the exercise group than in the control group at the L4 and hip. Although the exercise program in this study may probably reduce the rate of bone loss in weight-bearing skeletal sites, we do not suggest the exercise by itself be viewed as prevention or treatment for osteoporosis. Further, the exact dose-response relationship of exercise and bone mass in early postmenopause is not clear.

关键词： early postmenopausal women     bone mineral density     exercise     effects    

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density measurement for plastic injection molding via ultrasonic technology

《机械工程前沿（英文）》 2022年 第17卷 第4期 doi: 10.1007/s11465-022-0714-2

摘要： Density variation during the injection molding process directly reflects the state of plastic melt and contains valuable information for process monitoring and optimization. Therefore, in-situ density measurement is of great interest and has significant application value. The existing methods, such as pressure−volume−temperature (PVT) method, have the shortages of time-delay and high cost of sensors. This study is the first to propose an in-situ density measurement method using ultrasonic technology. The analyses of the time-domain and frequency-domain signals are combined in the proposed method. The ultrasonic velocity is obtained from the time-domain signals, and the acoustic impedance is computed through a full-spectral analysis of the frequency-domain signals. Experiments with different process conditions are conducted, including different melt temperature, injection speed, material, and mold structure. Results show that the proposed method has good agreement with the PVT method. The proposed method has the advantages of in-situ measurement, non-destructive, high accuracy, low cost, and is of great application value for the injection molding industry.

关键词： ultrasonic measurement     melt density     in-situ measurement     injection molding    

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Phytotoxicity in seven higher plant species exposed to di-

Tingting MA,Ying TENG,Peter CHRISTIE,Yongming LUO

《环境科学与工程前沿（英文）》 2015年 第9卷 第2期   页码 259-268 doi: 10.1007/s11783-014-0652-2

摘要： We investigated phytotoxicity in seven plant species exposed to a range of concentrations (0– 500 mg·kg soil) of di- -butyl phthalate (DnBP) or bis (2-ethylhexyl) phthalate (DEHP), two representative phthalate esters (PAEs) nominated by USEPA as priority pollutants and known environmental estrogens. We studied seed germination, root elongation, seedling growth, biomass (fresh weight, FW) and malondialdehyde (MDA) content of shoots and roots of wheat ( L.), alfalfa ( L.), perennial ryegrass ( ), radish ( L.), cucumber ( L.), oat ( ) and onion ( L.), together with monitoring of plant pigment content (chlorophyll a, b and carotinoids) in alfalfa, radish and onion shoots. Root elongation, seedling growth and biomass of the test species were generally inhibited by DnBP but not by DEHP, indicating a lower level of phytotoxicity of DEHP than of DnBP. MDA contents of four species were promoted by PAE exposure, but not in alfalfa, ryegrass or onion shoots, indicating lower sensitivity of these three species to PAE pollutants. Plant pigment contents were clearly affected under the stress of both pollutants, implying the potential damage to the photosynthetic system of test plants, mainly by decreasing the content of chlorophyll a and b. Results of DnBP and DEHP phytotoxicity to the primary growth of test plants has provided information for the assessment of their environmental risk in the soil and also forms a basis for the further analysis of their toxic effects over the whole growth period of different plant species.

关键词： phytotoxicity     di-n-butyl phthalate     bis(2-ethylhexyl) phthalate     malondialdehyde     plant pigments (chlorophyll a     b and carotinoids)    

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Isolating higher yielding and more stable rice genotypes in stress environments: fine-tuning a selection

《农业科学与工程前沿（英文）》 doi: 10.15302/J-FASE-2023521

摘要：

● Score index methods readily discriminate genotypes adapted to a target environment.

关键词： Aerobic rice     breeding selection     drought resilience     production capacity index     resilience capacity index     stress score index     upland    

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Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

《医学前沿（英文）》 2007年 第1卷 第4期   页码 398-400 doi: 10.1007/s11684-007-0077-4

摘要： The aim of this paper was to investigate the relationship between the expression of adrenomedullin (ADM) and microvessel density (MVD) and prognosis in smooth muscle tumor of uterus. The expression of ADM was detected using immunohistochemical staining in specimens from 15 normal controls, 28 cases of uterine leiomyoma (LE) and 19 cases of uterine leiomyosarcoma (LES). The MVD was assayed by immunostainting with CD. There was a positive correlation between the ADM expression and MVD in LE and LES respectively ( = 0.823, <0.01; = 0.793, <0.01). The expression of ADM in LE was statistically lower than that in LES (<0.05). There was a positive correlation between the ADM expression and mitotic figures in LES (<0.05): the more mitotic figures, the higher levels of the ADM expression and poor prognosis. The ADM is an important angiogenic factor in smooth muscle tumor of uterus. The ADM can be used as an accessory marker in estimating the malignant potency of LE and judging the pro gnosis of LES, and as a novel molecular target of anti-angiogenic and anticarcinogenic strategies.

关键词： anticarcinogenic     microvessel density     malignant potency     muscle     uterine leiomyosarcoma    

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Single-electromagnet levitation for density measurement and defect detection

Yuhan JIA, Peng ZHAO, Jun XIE, Xuechun ZHANG, Hongwei ZHOU, Jianzhong FU

《机械工程前沿（英文）》 2021年 第16卷 第1期   页码 186-195 doi: 10.1007/s11465-020-0608-0

摘要： This paper presents a single-electromagnet levitation device to measure the densities and detect the internal defects of antimagnetic materials. The experimental device has an electromagnet in its lower part and a pure iron core in the upper part. When the electromagnet is activated, samples can be levitated stably in a paramagnetic solution. Compared with traditional magnetic levitation devices, the single-electromagnet levitation device is adjustable. Different currents, electromagnet shapes, and distances between the electromagnet and iron core are used in the experiment depending on the type of samples. The magnetic field formed by the electromagnet is strong. When the concentration of the MnCl aqueous solution is 3 mol/L, the measuring range of the single-electromagnet levitation device ranges from 1.301 to 2.308 g/cm . However, with the same concentration of MnCl aqueous solution (3 mol/L), the measuring range of a magnetic levitation device built with permanent magnets is only from 1.15 to 1.50 g/cm . The single-electromagnet levitation device has a large measuring range and can realize accurate density measurement and defect detection of high-density materials, such as glass and aluminum alloy.

关键词： single-electromagnet     electromagnetic levitation     density measurement     defect detection    

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Application of gamma-ray attenuation technology in density measurement of a slurry reactor

Jian XU, Weisheng WEI, Kai ZHANG

《化学科学与工程前沿（英文）》 2010年 第4卷 第4期   页码 486-490 doi: 10.1007/s11705-010-0509-6

摘要： Axial density profile of the gas-liquid-solid mixture in a slurry bubble column was measured by gamma-ray attenuation technology. Several measures for improving measurement precision were presented based on the discussion on attenuation law. It was found that the response frequency and the ray intensity should be as high as possible to improve the measurement precision. The mass absorption coefficient depended on not the object’s thickness but the location where the object was placed between the ray source and the detector. The results showed that the density in the column decreases with the increase of column height, which indicates that the measurement by gamma-ray attenuation is reasonable.

关键词： slurry reactor     axial density distribution     gamma-ray attenuation technology    

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标题 作者 时间 类型 操作

Lymphatic metastasis is related to the epithelial-mesenchymal transition and expressions of VEGF, MMP-9, and COX-2 in breast cancer

Lihui WANG, Lianhong LI, Shen LV, Shujun FAN, Li ZHAN, Bo WANG, Zhong ZHANG

期刊论文

FUNCTIONAL GAIN OF FRUIT NETTED-CRACKING IN AN INTROGRESSION LINE OF TOMATO WITH HIGHER EXPRESSION OF

期刊论文

Higher-order mode effects on the seismic performance of tall piers

Zhongguo GUAN, Jianzhong LI, Yan XU, Hao LU

期刊论文

高等植物叶片色域的理论研究

程晓舫,董金一,范学良,丁金磊

期刊论文

工程结构可靠性分析的高阶矩法研究

宫凤强,李夕兵,邓建

期刊论文

Higher heating value prediction of torrefaction char produced from non-woody biomass

Nitipong SOPONPONGPIPAT,Dussadeeporn SITTIKUL,Unchana SAE-UENG

期刊论文

Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai Integration Model (SIM)

期刊论文

Effect of current density on groundwater arsenite removal performance using air cathode electrocoagulation

期刊论文

Effects of exercise therapy on bone mineral density in early postmenopausal women: a controlled trial

Shilin DENG MD ,

期刊论文

density measurement for plastic injection molding via ultrasonic technology

期刊论文

Phytotoxicity in seven higher plant species exposed to di-

Tingting MA,Ying TENG,Peter CHRISTIE,Yongming LUO

期刊论文

Isolating higher yielding and more stable rice genotypes in stress environments: fine-tuning a selection

期刊论文

Relationship of adrenomedullin expression and microvessel density and prognosis in smooth muscle tumor

JIANG Yuan, TIAN Xuehong, YUAN Jie, JIN Yuemei, TAN Yusong

期刊论文

Single-electromagnet levitation for density measurement and defect detection

Yuhan JIA, Peng ZHAO, Jun XIE, Xuechun ZHANG, Hongwei ZHOU, Jianzhong FU

期刊论文

Application of gamma-ray attenuation technology in density measurement of a slurry reactor

Jian XU, Weisheng WEI, Kai ZHANG

期刊论文